| Indication
|
Dose and Duration
|
| Fetal/neonatal alloimmune thrombocytopenia, maternal
|
up to 2 g/kg weekly starting at 12-16 weeks gestation if previous fetus with intracranial hemorrhage, of up to 1 g/kg weekly starting at 20-26 weeks gestation otherwise
|
| Fetal/neonatal alloimmune thrombocytopenia, infant
|
1 g/kg and reassess
|
| Hemolytic disease of the fetus and newborn
|
0.5 g/kg over 4 hours
|
| Immune thrombocytopenia, adult, acute
|
1 g/kg as a single dose; repeat if platelets do not increase by at least 30
|
| Immune thrombocytopenia, adult, chronic
|
1-2 g/kg, as directed by a hematologist
|
| Immune thrombocytopenia, pediatric
|
0.8 to 1 mg/kg as a single dose; can be repeated if no response
|
| Post-transfusion purpura
|
up to 2 g/kg divided over 2 to 5 consecutive days; repeat if necessary
|
| Pemphigus vulgaris
|
2 g/kg divided over 2 to 5 days every 4 weeks, then every 6 weeks after 6 months of therapy
|
| Juvenile idiopathic inflammatory myopathy
|
2 g/kg initial divided over 2 days as initial dose, followed by maintenance dose of up to 2 g/kg total
|
| Kawasaki disease
|
2 g/kg for 1 day; can be repeated if no response
|
| Idiopathic inflammatory myopathy, including dermatomyositis and polymyositis
|
up to 2 g/kg over 2 days monthly for 3 to 6 months, then continued at decreasing freuqncy over 2 years
|
| Primary and secondary immunodeficiency, adult
|
0.4 to 0.6 g/kg every 3 to 4 weeks
|
| Primary and secondary immunodeficiency, pediatric
|
0.3 to 0.6 g/kg every 3 to 4 weeks, targetting tough of 700 mg/dL
|
| Hematopoietic stem cell transplant in primary immunodeficiency
|
0.4-0.6 g/kg every 3 to 4 weeks
|
| Kidney transplant from living donor to whom the patient is sensitized
|
2 g/kg monthly for 4 months
|
| Pre-transplant heart
|
up to 1 g/kg monthly until transplant
|
| Peri-transplant heart, lung, kidney, or pancreas
|
1 g/kg in divided doses with a course of plasmapheresis
|
| Post-transplant, acute
|
1 g/kg/dose, can be divided if also getting plasmaphereesis
|
| Post-transplant, chronic
|
1 g/kg monthly
|
| Streptococcal toxic shock syndrome
|
1 g/kg on day one follower by 0.5 mg/kg daily for 2 days, or 0.15 g/kg daily for 5 days
|
| Staphylococcal toxic shock syndrome
|
1 g/kg on day one follower by 0.5 mg/kg daily for 2 days, or 0.15 g/kg daily for 5 days
|
