Granulomatous disease

From IDWiki

Background

  • Granulomatous inflammation is chronic inflammation that involves macrophages and T lymphocytes to wall off an infectious organism
  • T cells are activated and in turn activate macrophages, which undergo morphological changes to become more epithelioid
  • Creates two main types of granulomas: foreign body granulomas, and immune ganulomas
    • In immune granulomas, macrophages active T cells to produce IL-2

Differential Diagnosis

Further Reading

  • James DG. A clinicopathological classification of granulomatous disorders. Postgrad Medical J. 2000;76:457-465. doi: 10.1136/pmj.76.898.457