Fungal keratitis

Background

• Infection of the cornea
• See also eye:Fungal Keratitis
• Typically caused by traumatic inoculation

Microbiology

• Yeast including Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsilosis
• Filamentous fungi including Aspergillus, Fusarium, Cladosporium, Curvalaria, and Rhizopus

Clinical Manifestations

• As for other causes of keratitis
• Blurry vision, redness, tearing, photophobia, pain, foreign body sensation, secretions

Management

• Topical antifungals are the mainstay of treatment
  • Topical natamycin 5%, but also topical voriconazole 1% dilution (50 µg/0.1 mL for injection), caspofungin, and others
• Sometimes oral antifungals
  • Voriconazole
  • Posaconazole
  • Maybe others, depending on the species