Ceftazidime

Background

• Third-generation cephalosporin antibiotic with antipseudomonal activity

Spectrum of Activity

• Gram-negatives, including resistant Gram-negatives such as Pseudomonas aeruginosa
• Weaker activity against Gram-positive bacteria than ceftriaxone and cefipime, and usually avoided for Streptococcus pneumoniae

Dosing

• Urinary tract infections
  • Uncomplicated: 250 mg IV every 12 hours
  • Complicated: 500 mg IV every 8 to 12 hours
• Mild to moderate infections: 1 g IV every 8 to 12 hours
• Severe infections or meningitis: 2 g IV every 8 hours
• Cystic fibrosis pulmonary exacerbation involving Pseudomonas aeruginosa: up to 2 g IV every 6 hours
• Melioidosis: 2 g IV every 6 to 8 hours, ideally by continuous infusion