Tocilizumab: Difference between revisions

Revision as of 14:53, 25 February 2021

SARS-CoV-2 with acutely declining patients, as a single dose infused over 60 minutes
- Weight ≤40 kg: 8 mg/kg
- Weight >40 and ≤65 kg: 400 mg
- Weight >65 and ≤90 kg: 600 mg
- Weight >90 kg: 800 mg

In one cohort study, serious bacterial infections occured in about 7%, with no viral or fungal infections seen1
Compared to TNF-α inhibitors, has a higher risk of serious bacterial infection, skin and soft tissue infection, and diverticulitis2

^ Veronika R. Lang, Matthias Englbrecht, Jürgen Rech, Hubert Nüsslein, Karin Manger, Florian Schuch, Hans-Peter Tony, Martin Fleck, Bernhard Manger, Georg Schett, Jochen Zwerina. Risk of infections in rheumatoid arthritis patients treated with tocilizumab. Rheumatology. 2011;51(5):852-857. doi:10.1093/rheumatology/ker223.
^ Ajinkya Pawar, Rishi J Desai, Daniel H Solomon, Adrian J Santiago Ortiz, Sara Gale, Min Bao, Khaled Sarsour, Sebastian Schneeweiss, Seoyoung C Kim. Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: a multidatabase cohort study. Annals of the Rheumatic Diseases. 2019;78(4):456-464. doi:10.1136/annrheumdis-2018-214367.

@@ Line 11: / Line 11: @@
 **Weight >90 kg: 800 mg
-== Safety ==
+==Safety==
-=== Infections ===
+===Infections===
+*In one cohort study, serious bacterial infections occured in about 7%, with no viral or fungal infections seen[[CiteRef::lang2011ri]]
-* Compared to [[TNF-α inhibitors]], has a higher risk of serious bacterial infection, [[skin and soft tissue infection]], and [[diverticulitis]][[CiteRef::pawar2019ri]]
-* There does not appear to be an increased risk of non-bacterial infections[[CiteRef::lang2011ri]]
+*Compared to [[TNF-α inhibitors]], has a higher risk of serious bacterial infection, [[skin and soft tissue infection]], and [[diverticulitis]][[CiteRef::pawar2019ri]]
 [[Category:Medications]]