Tissue penetration of antimicrobials: Difference between revisions

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|β-lactamase inhibitors
  
|β-lactamase inhibitors
 
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|[[ampicillin]]
  
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| rowspan="4" |Cephalosporins
  
| rowspan="4" |Cephalosporins
 
|first-generation cephalosporins
  
|first-generation cephalosporins
 
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|second-generation cephalosporins
  
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|[[ceftazidime]]
  
|[[ceftazidime]]
 
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| rowspan="2" |Cephamycins
  
| rowspan="2" |Cephamycins
 
|[[cephamycins]]
  
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|Carbapenems
  
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! colspan="7" |Antibiotics: Non-β-Lactams
  
! colspan="7" |Antibiotics: Non-β-Lactams
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|Chloramphenicol
  
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|Fluoroquinolones
  
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|Lincosamides
  
|Lincosamides
 
|[[clindamycin]]
  
|[[clindamycin]]
 
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|Macrolides
  
|Macrolides
 
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|Nitrofurans
  
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|Nitroimidazoles
  
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|Rifamycins
  
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|[[tetracyclines]]
  
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! colspan="7" |Antifungals
  
! colspan="7" |Antifungals
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[[Category:Antimicrobials]]
  
[[Category:Antimicrobials]]

Revision as of 12:21, 24 August 2020

Class Antimicrobial Blood CNS Urine Prostate Necrotic
Antibiotics: β-Lactams
Penicillins β-lactamase inhibitors –
ampicillin + –
Cephalosporins first-generation cephalosporins – –
second-generation cephalosporins –
cefepime +
ceftazidime + +
Cephamycins cephamycins –
cefoxitin –
Carbapenems imipenem +
Antibiotics: Non-β-Lactams
Aminoglycosides –
Chloramphenicol chloramphenicol +
Fluoroquinolones –? + +
Lincosamides clindamycin – +
Macrolides macrolides – +
Nitrofurans nitrofurantoin – – + – –
Nitroimidazoles metronidazole +
Rifamycins rifampin +
Sulfonamides sulfamethoxazole –
Tetracyclines tetracyclines – +
doxycycline +
Antifungals
Azoles fluconazole +

References

  1. ^ nau2010pe 
  2. ^  Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.
  3. a b c d e f g h i j k l m n o p q r  L. Brockhaus, D. Goldblum, L. Eggenschwiler, S. Zimmerli, C. Marzolini. Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics. Clinical Microbiology and Infection. 2019;25(11):1364-1369. doi:10.1016/j.cmi.2019.01.017.
  4. a b  Takashi Suzuki, Toshihiko Uno, Guangming Chen, Yuichi Ohashi. Ocular distribution of intravenously administered micafungin in rabbits. Journal of Infection and Chemotherapy. 2008;14(3):204-207. doi:10.1007/s10156-008-0612-5.
  5. a b c d e f g h  T. Felton, P. F. Troke, W. W. Hope. Tissue Penetration of Antifungal Agents. Clinical Microbiology Reviews. 2014;27(1):68-88. doi:10.1128/cmr.00046-13.
  6. ^  Tony H. Huynh, Mark W. Johnson, Grant M. Comer, Douglas N. Fish. Vitreous Penetration of Orally Administered Valacyclovir. American Journal of Ophthalmology. 2008;145(4):682-686. doi:10.1016/j.ajo.2007.11.016.
  7. ^  Luis F. López-Cortés, R. Ruiz-Valderas, M. J. Lucero-Muñoz, E. Cordero, M. T. Pastor-Ramos, J. Marquez. Intravitreal, Retinal, and Central Nervous System Foscarnet Concentrations after Rapid Intravenous Administration to Rabbits. Antimicrobial Agents and Chemotherapy. 2000;44(3):756-759. doi:10.1128/aac.44.3.756-759.2000.

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