Rifampin

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Inhibits bacterial DNA-dependent RNA polymerase
Never given alone due to rapid resistance
Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
Avoid in liver failure

Dosing

As adjunct to fluoroquinolone for Staphylococcus aureus:
- Weight <60 kg: 600 mg p.o. daily
- Weight >60 kg: 450 mg p.o. twice daily

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Rifamycins