Rifampin: Difference between revisions
From IDWiki
No edit summary |
No edit summary |
||
(One intermediate revision by the same user not shown) | |||
Line 1: | Line 1: | ||
+ | == Background == |
||
* Inhibits bacterial DNA-dependent RNA polymerase |
* Inhibits bacterial DNA-dependent RNA polymerase |
||
* Never given alone due to rapid resistance |
* Never given alone due to rapid resistance |
||
⚫ | |||
⚫ | |||
== Dosing == |
== Dosing == |
||
Line 9: | Line 8: | ||
** Weight <60 kg: 600 mg p.o. daily |
** Weight <60 kg: 600 mg p.o. daily |
||
** Weight >60 kg: 450 mg p.o. twice daily |
** Weight >60 kg: 450 mg p.o. twice daily |
||
+ | |||
+ | == Safety == |
||
+ | |||
⚫ | |||
+ | |||
+ | === Adverse Effects === |
||
+ | |||
+ | * Orange or red discoloration of body fluids |
||
⚫ | |||
+ | * Drug-drug interactions |
||
+ | * Flu-like syndrome<ref>Dhhar G, McColl J, Kitai I, Levy DM, Verstegen RHJ. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. <abbr>''CMAJ.''</abbr> 2023;195(34):E1151-E1153. DOI: [https://doi.org/10.1503/cmaj.230317 10.1503/cmaj.230317]</ref>, a type III [[hypersensitivity reaction]] characterized by fevers, chills, myalgias, and arthalgias usually 1-4 hours (but up to 12 hours) after a dose, and lasts for 8 hours; if rechallenged, can develop hypotension and shock |
||
+ | |||
+ | === Drug-Drug Interactions === |
||
+ | |||
+ | * Multiple |
||
+ | * Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]] |
||
[[Category:Rifamycins]] |
[[Category:Rifamycins]] |
Latest revision as of 13:29, 10 December 2023
Background
- Inhibits bacterial DNA-dependent RNA polymerase
- Never given alone due to rapid resistance
Dosing
- As adjunct to fluoroquinolone for Staphylococcus aureus:
- Weight <60 kg: 600 mg p.o. daily
- Weight >60 kg: 450 mg p.o. twice daily
Safety
- Avoid in liver failure
Adverse Effects
- Orange or red discoloration of body fluids
- Drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
- Drug-drug interactions
- Flu-like syndrome[1], a type III hypersensitivity reaction characterized by fevers, chills, myalgias, and arthalgias usually 1-4 hours (but up to 12 hours) after a dose, and lasts for 8 hours; if rechallenged, can develop hypotension and shock
Drug-Drug Interactions
- Multiple
- Other antibiotics include clindamycin, doxycycline, linezolid, moxifloxacin, trimethoprim, and fusidic acid
- ↑ Dhhar G, McColl J, Kitai I, Levy DM, Verstegen RHJ. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. CMAJ. 2023;195(34):E1151-E1153. DOI: 10.1503/cmaj.230317