Rheumatologic serologies: Difference between revisions
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| − | ! |
+ | !Test |
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+ | !Association |
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+ | !Correlates with dz activity? |
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+ | |ANA |
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+ | |[[SLE]] |
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+ | |No |
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+ | |ANA (centromere pattern) |
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+ | |[[CREST syndrome]], [[Systemic sclerosis|SSc]], PH |
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+ | |Anti-Smith |
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+ | |[[SLE]] (most specific) |
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+ | |No |
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+ | |Anti-dsDNA |
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+ | |[[SLE]] |
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+ | |Yes, especially renal disease |
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+ | |Anti-histone |
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+ | |[[Drug-induced lupus]] |
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+ | |Anti-U1-RNP |
| − | | Mixed CTD |
+ | |[[Mixed connective tissue disease|Mixed CTD]] |
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+ | |Anti-Ro/SS-A |
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+ | |[[Sjögren syndrome]], neonatal heart block, [[Systemic lupus erythematosus|subacute SLE]] |
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+ | |Anti-Ro/SS-A 60 kDa |
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| + | |- |
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| + | |Anti-Ro/SS-A 52 kDa |
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| + | |[[Systemic sclerosis]] and [[SLE]], often with other antibodies present[[CiteRef::hervier2009cl]] |
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| + | |- |
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| + | |Anti-La/SSB |
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| + | |- |
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| + | |Anti-Scl-70 |
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+ | |Anti-Jo-1 |
| + | |[[Polymyositis]], [[antisynthetase syndrome]] |
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+ | |Anti-CCP |
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| − | | Polymyositis<br/>Antisynthetase syndrome |
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+ | |Anti-smooth muscle |
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+ | |Anti-PR3 (cANCA) |
| + | |[[Granulomatosis with polyangiitis|GPA]] |
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+ | |Anti-MPO (pANCA) |
| + | |[[Microscopic polyangiitis|MPA]] and [[Eosinophilic granulomatosis with polyangiitis|eGPA]] |
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| − | | GPA |
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+ | |Anti-parietal cell antibodies |
| + | |[[Autoimmune gastritis]] and [[pernicious anemia]]; also [[Addison disease]], [[autoimmune thyroiditis]], [[type 1 diabetes mellitus]], and [[primary ovarian failure]] |
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| − | | MPA and eGPA |
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Latest revision as of 11:19, 17 July 2021
| Test | Association | Correlates with dz activity? |
|---|---|---|
| ANA | SLE | No |
| ANA (centromere pattern) | CREST syndrome, SSc, PH | |
| Anti-Smith | SLE (most specific) | No |
| Anti-dsDNA | SLE | Yes, especially renal disease |
| Anti-histone | Drug-induced lupus | |
| Anti-U1-RNP | Mixed CTD | |
| Anti-Ro/SS-A | Sjögren syndrome, neonatal heart block, subacute SLE | |
| Anti-Ro/SS-A 60 kDa | ||
| Anti-Ro/SS-A 52 kDa | Systemic sclerosis and SLE, often with other antibodies present1 | |
| Anti-La/SSB | Sjögren syndrome, sicca syndrome, neonatal SLE | |
| Anti-Scl-70 | SSc and pulmonary fibrosis, dcSSc | |
| Anti-Jo-1 | Polymyositis, antisynthetase syndrome | |
| Anti-CCP | RA (most specific) | |
| Anti-smooth muscle | Autoimmune hepatitis | |
| Anti-PR3 (cANCA) | GPA | |
| Anti-MPO (pANCA) | MPA and eGPA | |
| Anti-parietal cell antibodies | Autoimmune gastritis and pernicious anemia; also Addison disease, autoimmune thyroiditis, type 1 diabetes mellitus, and primary ovarian failure |
References
- ^ B. Hervier, M. Rimbert, F. Colonna, M. A. Hamidou, M. Audrain. Clinical significance of anti-Ro/SSA-52 kDa antibodies--a retrospective monocentric study. Rheumatology. 2009;48(8):964-967. doi:10.1093/rheumatology/kep145.
