Powassan virus: Difference between revisions
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** ''[[Ixodes cookei]]'', ''[[Ixodes scapularis]]'', ''[[Ixodes marxi]]'', ''[[Ixodes spinipalpus]]'', ''[[Dermacentor andersoni]]'', and ''[[Dermacentor variabilis]]'' |
** ''[[Ixodes cookei]]'', ''[[Ixodes scapularis]]'', ''[[Ixodes marxi]]'', ''[[Ixodes spinipalpus]]'', ''[[Dermacentor andersoni]]'', and ''[[Dermacentor variabilis]]'' |
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+ | == Clinical Manifestations == |
* Incubation period 1 to 3 weeks |
* Incubation period 1 to 3 weeks |
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* Fever, headache, confusion, weakness, encephalopathy, focal neurological deficits, and vomiting |
* Fever, headache, confusion, weakness, encephalopathy, focal neurological deficits, and vomiting |
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Revision as of 06:46, 2 August 2020
- Tick-borne viral infection that can cause encephalitis
- Closely related to deer tick virus
- Named for Pawassan, Ontario, but endemic in Eurasia and North America
Background
Microbiology
- Single-stranded positive-sense RNA virus in the genus Flavivirus, family Flaviviridae
- Two genotypes: lineage 1 and lineage 2
Epidemiology
- Transmitted by a number of Ixodes and Dermacentor ticks
Clinical Manifestations
- Incubation period 1 to 3 weeks
- Fever, headache, confusion, weakness, encephalopathy, focal neurological deficits, and vomiting
- Progresses to severe encephalitis
Diagnosis
- Serologic with IgM, using screening ELISA followed by confirmatory PRNT
Management
- Supportive
Prognosis
- Mortality is 10%, with survivors having permanent neurologic sequelae
