Posaconazole: Difference between revisions

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*For treatment, target trough >1 mg/L
  
*For treatment, target trough >1 mg/L
   
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===Clinical Breakpoints===
−
=== Epidemiologic Cutoff Values ===
  
 
{| class="wikitable"
  
{| class="wikitable"
−
!Species
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! rowspan="2" |Species
−
!ECV (mcg/mL)
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! rowspan="2" |ECV (μg/mL)
  +
! colspan="4" |Breakpoints (μg/mL)
  +
! colspan="4" |Breakpoints (mm)
 
|-
  
|-
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!S
−
|C. albicans
  
  +
!SDD
  +
!I
  +
!R
  +
!S
  +
!SDD
  +
!I
  +
!R
  +
|-
  +
|[[Candida albicans]]
 
|0.06
  
|0.06
  +
|≤0.06
  +
|
  +
|
  +
|≥0.12
  +
|
  +
|
  +
|
  +
|
 
|-
  
|-
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|[[Candida dubliniensis]]
−
|C. glabrata
  
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
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|-
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|[[Candida glabrata]]
 
|2
  
|2
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
 
|-
  
|-
  +
|[[Candida guilliermondii]]
−
|C. parapsilosis
  
  +
|0.5
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida kefyr]]
 
|0.25
  
|0.25
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
 
|-
  
|-
  +
|[[Candida krusei]]
−
|C. tropicalis
  
  +
|0.5
  +
| colspan="4" |
  +
| colspan="4" |
  +
|-
  +
|[[Candida lusitaniae]]
 
|0.12
  
|0.12
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
 
|-
  
|-
  +
|[[Candida parapsilosis]]
−
|C. krusei
  
−
|0.5
 +
|0.25
  +
|≤0.06
  +
|
  +
|
  +
|≥0.12
  +
|
  +
|
  +
|
  +
|
 
|-
  
|-
  +
|[[Candida tropicalis]]
−
|C. lusitaniae
  
 
|0.12
  
|0.12
  +
|≤0.06
  +
|
  +
|
  +
|≥0.12
  +
|
  +
|
  +
|
  +
|
 
|-
  
|-
  +
|[[Cryptococcus neoformans]]
−
|C. guilliermondii
  
−
|0.5
 +
|
  +
| colspan="8" rowspan="2" |
 
|-
  
|-
  +
|[[Cryptococcus gattii]]
−
|C. kefyr
  
  +
|
−
|0.25
  
 
|}
  
|}
 
[[Category:Triazoles]]
  
[[Category:Triazoles]]

Revision as of 21:12, 19 January 2021

Therapeutic Drug Monitoring

  • Measure trough 7 days after starting or adjusting dose, or adjusting interacting medications, or concerns of poor adherence or absorption
  • For prophylaxis, target trough >0.7 mg/L, or random level 0.35 mg/L 48 h after starting therapy
  • For treatment, target trough >1 mg/L

Clinical Breakpoints

Species ECV (μg/mL) Breakpoints (μg/mL) Breakpoints (mm)
S SDD I R S SDD I R
Candida albicans 0.06 ≤0.06 ≥0.12
Candida dubliniensis
Candida glabrata 2
Candida guilliermondii 0.5
Candida kefyr 0.25
Candida krusei 0.5
Candida lusitaniae 0.12
Candida parapsilosis 0.25 ≤0.06 ≥0.12
Candida tropicalis 0.12 ≤0.06 ≥0.12
Cryptococcus neoformans
Cryptococcus gattii
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