Piperacillin-tazobactam: Difference between revisions

Latest revision as of 11:07, 9 January 2024

Species	ECV (μg/mL)	Breakpoints (μg/mL)			Breakpoints (mm)
Species	ECV (μg/mL)	S	I	R	S	I	R
Enterobacterales		≤16/4	32/4-64/4	≥128/4	≥21	18-20	≤17
Pseudomonas aeruginosa		≤16/4	32/4-64/4	≥128/4	≥21	15-20	≤14
Acinetobacter		≤16/4	32/4-64/4	≥128/4	≥21	18-20	≤17
Other non-Enterobacterales		≤16/4	32/4-64/4	≥128/4
Anaerobes		≤16/4	32/4-64/4	≥128/4
Haemophilus influenzae and Haemophilus parainfluenzae		≤1/4	—	≥2/4	≥21	—	—
Gram-positive bacteria	susceptibility predicted by penicillin

CrCl	Standard	Pseudomonas	Notes
>30	3.375 g q6h	4.5 g q6h
10-29	3.375 g q8h	4.5 g q8h
<10	3.375 g q12h	4.5 g q12h
PD	3.375 g q12h	4.5 g q12h
HD	3.375 g q12h	4.5 g q12h	On dialysis days, given towards the end of dialysis
CRRT	3.375 g q6h	4.5 g q6h
SLED	3.375 g q12-18h	4.5 g q12-18h	Depends on severity of illness and intensity of SLED dialysis

@@ Line 71: / Line 71: @@
 |Gram-positive bacteria
 | colspan="7" |susceptibility predicted by [[penicillin]]
+|}
+== Dosing ==
+* Standard dose: 3.375 g IV every 6 hours
+* [[Pseudomonas aeruginosa|Pseudomonas]] dose: 4.5 g IV every 6 hours
+=== Renal Dosing ===
+{| class="wikitable"
+!CrCl
+!Standard
+![[Pseudomonas aeruginosa|Pseudomonas]]
+!Notes
+|-
+|>30
+|3.375 g q6h
+|4.5 g q6h
+|
+|-
+|10-29
+|3.375 g q8h
+|4.5 g q8h
+|
+|-
+|<10
+|3.375 g q12h
+|4.5 g q12h
+|
+|-
+|PD
+|3.375 g q12h
+|4.5 g q12h
+|
+|-
+|HD
+|3.375 g q12h
+|4.5 g q12h
+|On dialysis days, given towards the end of dialysis
+|-
+|CRRT
+|3.375 g q6h
+|4.5 g q6h
+|
+|-
+|SLED
+|3.375 g q12-18h
+|4.5 g q12-18h
+|Depends on severity of illness and intensity of SLED dialysis
 |}
 [[Category:Β-lactams]]