Piperacillin-tazobactam: Difference between revisions
From IDWiki
m (Text replacement - " species]]" to "]]") |
No edit summary |
||
Line 71: | Line 71: | ||
|Gram-positive bacteria |
|Gram-positive bacteria |
||
| colspan="7" |susceptibility predicted by [[penicillin]] |
| colspan="7" |susceptibility predicted by [[penicillin]] |
||
+ | |} |
||
+ | |||
+ | == Dosing == |
||
+ | |||
+ | * Standard dose: 3.375 g IV every 6 hours |
||
+ | * [[Pseudomonas aeruginosa|Pseudomonas]] dose: 4.5 g IV every 6 hours |
||
+ | |||
+ | === Renal Dosing === |
||
+ | {| class="wikitable" |
||
+ | !CrCl |
||
+ | !Standard |
||
+ | ![[Pseudomonas aeruginosa|Pseudomonas]] |
||
+ | !Notes |
||
+ | |- |
||
+ | |>30 |
||
+ | |3.375 g q6h |
||
+ | |4.5 g q6h |
||
+ | | |
||
+ | |- |
||
+ | |10-29 |
||
+ | |3.375 g q8h |
||
+ | |4.5 g q8h |
||
+ | | |
||
+ | |- |
||
+ | |<10 |
||
+ | |3.375 g q12h |
||
+ | |4.5 g q12h |
||
+ | | |
||
+ | |- |
||
+ | |PD |
||
+ | |3.375 g q12h |
||
+ | |4.5 g q12h |
||
+ | | |
||
+ | |- |
||
+ | |HD |
||
+ | |3.375 g q12h |
||
+ | |4.5 g q12h |
||
+ | |On dialysis days, given towards the end of dialysis |
||
+ | |- |
||
+ | |CRRT |
||
+ | |3.375 g q6h |
||
+ | |4.5 g q6h |
||
+ | | |
||
+ | |- |
||
+ | |SLED |
||
+ | |3.375 g q12-18h |
||
+ | |4.5 g q12-18h |
||
+ | |Depends on severity of illness and intensity of SLED dialysis |
||
|} |
|} |
||
[[Category:Β-lactams]] |
[[Category:Β-lactams]] |
Latest revision as of 11:07, 9 January 2024
Background
Clinical Breakpoints
Species | ECV (μg/mL) | Breakpoints (μg/mL) | Breakpoints (mm) | ||||
---|---|---|---|---|---|---|---|
S | I | R | S | I | R | ||
Enterobacterales | ≤16/4 | 32/4-64/4 | ≥128/4 | ≥21 | 18-20 | ≤17 | |
Pseudomonas aeruginosa | ≤16/4 | 32/4-64/4 | ≥128/4 | ≥21 | 15-20 | ≤14 | |
Acinetobacter | ≤16/4 | 32/4-64/4 | ≥128/4 | ≥21 | 18-20 | ≤17 | |
Other non-Enterobacterales | ≤16/4 | 32/4-64/4 | ≥128/4 | ||||
Anaerobes | ≤16/4 | 32/4-64/4 | ≥128/4 | ||||
Haemophilus influenzae and Haemophilus parainfluenzae | ≤1/4 | — | ≥2/4 | ≥21 | — | — | |
Gram-positive bacteria | susceptibility predicted by penicillin |
Dosing
- Standard dose: 3.375 g IV every 6 hours
- Pseudomonas dose: 4.5 g IV every 6 hours
Renal Dosing
CrCl | Standard | Pseudomonas | Notes |
---|---|---|---|
>30 | 3.375 g q6h | 4.5 g q6h | |
10-29 | 3.375 g q8h | 4.5 g q8h | |
<10 | 3.375 g q12h | 4.5 g q12h | |
PD | 3.375 g q12h | 4.5 g q12h | |
HD | 3.375 g q12h | 4.5 g q12h | On dialysis days, given towards the end of dialysis |
CRRT | 3.375 g q6h | 4.5 g q6h | |
SLED | 3.375 g q12-18h | 4.5 g q12-18h | Depends on severity of illness and intensity of SLED dialysis |