Peripheral neuropathy: Difference between revisions
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| β | == |
+ | ==Differential Diagnosis== |
| β | * |
+ | *Mononeuropathy |
| β | ** |
+ | **Compression/injury |
| β | ** |
+ | **Infiltration |
| β | ** |
+ | **Mononeuritis |
| β | * |
+ | *[[Mononeuritis multiplex]] |
| β | ** |
+ | **[[Vasculitis]] |
| β | ** |
+ | **[[Diabetes]] |
| β | * |
+ | *Polyneuropathy |
| β | ** |
+ | **Axonal injury |
| β | *** |
+ | ***Neoplasm: [[carcinoma]], [[lymphoma]], [[MGUS]] |
| β | *** |
+ | ***Infection: [[sepsis]], chronic [[HIV]], [[Lyme disease]] |
| β | *** |
+ | ***Metabolic: [[diabetes]], [[uremia]] |
| β | *** |
+ | ***Vitamin deficiency: [[malabsorption]] |
| β | *** |
+ | ***Drugs: [[cisplatin]], [[taxanes]], [[vincristine]], [[isoniazid]], [[nucleoside analogues]] |
| β | ** |
+ | **Demyelinating |
| β | *** |
+ | ***[[Guillain-BarrΓ© syndrome]] |
| β | *** |
+ | ***Neoplasm: [[carcinoma]], [[lymphoma]], [[MGUS]]-IgM |
| β | *** |
+ | ***Drugs: [[taxanes]] |
| β | *** |
+ | ***[[Chronic inflammatory demyelinating polyradiculoneuropaty]] (CIDP) |
| β | * |
+ | *Amyloid polyneuropathy |
| β | * |
+ | *[[Charcot-Marie-Tooth disease]] |
| β | * |
+ | *[[Critical illness neuropathy]] |
| β | * |
+ | *[[Hypothyroidism]] |
| β | == |
+ | ==Investigations== |
| β | * |
+ | *Labs |
| β | ** |
+ | **CBC, lytes, creatinine, glucose, ESR/CRP, SPEP, vitamin B12, ANA, TSH, urinalysis |
| β | ** |
+ | **Based on presentation |
| β | *** |
+ | ***EMG and nerve conduction |
| β | *** |
+ | ***Nerve or muscle biopsy |
| β | *** |
+ | ***LP |
| β | *** |
+ | ***Lyme serology, HIV test, RPR/VDRL, HBV/HCV serology |
[[Category:Neurology]] |
[[Category:Neurology]] |
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Latest revision as of 20:59, 28 July 2020
Differential Diagnosis
- Mononeuropathy
- Compression/injury
- Infiltration
- Mononeuritis
- Mononeuritis multiplex
- Polyneuropathy
- Axonal injury
- Neoplasm: carcinoma, lymphoma, MGUS
- Infection: sepsis, chronic HIV, Lyme disease
- Metabolic: diabetes, uremia
- Vitamin deficiency: malabsorption
- Drugs: cisplatin, taxanes, vincristine, isoniazid, nucleoside analogues
- Demyelinating
- Guillain-BarrΓ© syndrome
- Neoplasm: carcinoma, lymphoma, MGUS-IgM
- Drugs: taxanes
- Chronic inflammatory demyelinating polyradiculoneuropaty (CIDP)
- Axonal injury
- Amyloid polyneuropathy
- Charcot-Marie-Tooth disease
- Critical illness neuropathy
- Hypothyroidism
Investigations
- Labs
- CBC, lytes, creatinine, glucose, ESR/CRP, SPEP, vitamin B12, ANA, TSH, urinalysis
- Based on presentation
- EMG and nerve conduction
- Nerve or muscle biopsy
- LP
- Lyme serology, HIV test, RPR/VDRL, HBV/HCV serology
