Monoclonal gammopathy of unknown significance

Background

• Also see multiple myeloma

Definition

• Proliferation of a single gamma globulin

Differential Diagnosis

• Neoplasm
  • Lymphoma
    • Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia)
    • Chronic lymphocytic leukemia
    • Follicular lymphoma
    • Diffuse large B-cell lymphoma
  • Multiple myeloma
• Infection
  • Hepatitis C
  • HIV
• Connective tissue diseases
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

Management

• Depends on underlying health