Periodic fever syndrome: Difference between revisions
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(Created page with "{| class="wikitable" ! !Ethnicity !Age at Onset !Duration !Lymphadenopathy !Abdo Pain !MSK !Chest Pain !Rash !Other !Treatment |- |FMF |Armenian, Arab, Jewish, Turkish |<2...") |
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|cervical |
|cervical |
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|very common |
|very common |
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+ | |arthralgias, rare arthritis |
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− | | |
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+ | |unusual |
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− | | |
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+ | |very common, maculopapular |
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− | | |
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+ | |[[hepatosplenomegaly]], [[Aphthous ulcer|aphthous ulcers]] |
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+ | |[[etanercept]], [[IL-1 inhibitor|IL-1 inhibitors]] |
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|[[NAPS12]] |
|[[NAPS12]] |
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|yes |
|yes |
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|urticaria/erythema |
|urticaria/erythema |
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− | |cold sensitivity, headache |
+ | |cold sensitivity, [[headache]] |
|— |
|— |
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|[[TRAPS]] |
|[[TRAPS]] |
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+ | |mostly northern European, but all ethnic groups |
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+ | |variable |
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+ | |more than 5 days, up to weeks to months |
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|common |
|common |
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+ | |common |
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− | | |
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+ | |arthralgias, myalgias |
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+ | |yes |
+ | |common erysipelas-like including arms |
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− | | |
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+ | |periorbital edema, [[headache]] |
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− | | |
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+ | |[[IL-1 inhibitor|IL-1 inhibitors]], [[TNF-α inhibitor|TNF-α inhibitors]], [[IL6R inhibitor|anti-IL6R mAb]] |
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|[[CAPS]] |
|[[CAPS]] |
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+ | |all ethnic groups |
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− | | |
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+ | |childhood/neonatal |
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+ | |variable, depending on subtype |
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+ | |rarerare |
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⚫ | |||
+ | |arthralgias, arthritis, bony overgrowth (depending on subtype) |
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− | | |
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− | | |
+ | |no |
+ | |[[urticaria]], erythema |
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− | | |
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+ | |cold sensitivity, [[deafness]], [[aseptic meningitis]], [[papilledema]], dysmorphism (depending on subtype) |
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+ | |[[IL-1 inhibitor|IL-1 inhibitors]] |
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|[[PFAPA]] |
|[[PFAPA]] |
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+ | |all ethnic groups |
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+ | |<5 years |
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+ | |3 to 6 days |
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+ | |cervical |
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− | | |
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+ | |common |
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+ | |arthralgias |
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+ | |rare |
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|common |
|common |
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+ | |[[aphthous stomatitis]], [[pharyngitis]], [[headache]] |
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− | | |
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+ | |[[corticosteroids]], [[cimetidine]], [[tonsillectomy]] |
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Revision as of 17:33, 24 April 2022
Ethnicity | Age at Onset | Duration | Lymphadenopathy | Abdo Pain | MSK | Chest Pain | Rash | Other | Treatment | |
---|---|---|---|---|---|---|---|---|---|---|
FMF | Armenian, Arab, Jewish, Turkish | <20 years | 1-4 days | rare | very common sterile peritonitis | monoarthritis of knee, ankle, wrist | pleuritis, often unilateral | rare erysipelas-like on legs | pericarditis, scrotal attacks, splenomegaly | colchicine |
HIDS | Dutch, French | childhood | 3-7 days | cervical | very common | arthralgias, rare arthritis | unusual | very common, maculopapular | hepatosplenomegaly, aphthous ulcers | etanercept, IL-1 inhibitors |
NAPS12 | Guadeloupe, Italy | neonatal | 2-10 days | yes | yes | arthralgias, myalgias | yes | urticaria/erythema | cold sensitivity, headache | — |
TRAPS | mostly northern European, but all ethnic groups | variable | more than 5 days, up to weeks to months | common | common | arthralgias, myalgias | yes | common erysipelas-like including arms | periorbital edema, headache | IL-1 inhibitors, TNF-α inhibitors, anti-IL6R mAb |
CAPS | all ethnic groups | childhood/neonatal | variable, depending on subtype | very rare | rarerare | arthralgias, arthritis, bony overgrowth (depending on subtype) | no | urticaria, erythema | cold sensitivity, deafness, aseptic meningitis, papilledema, dysmorphism (depending on subtype) | IL-1 inhibitors |
PFAPA | all ethnic groups | <5 years | 3 to 6 days | cervical | common | arthralgias | rare | common | aphthous stomatitis, pharyngitis, headache | corticosteroids, cimetidine, tonsillectomy |