Pemphigoid gestationis: Difference between revisions

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== Epidemiology ==
+
== Background ==
   
  +
===Epidemiology===
* 1 in 50,000 pregnancies
 
   
 
*1 in 50,000 pregnancies
== Clinical Manifestations ==
 
   
 
==Clinical Manifestations==
* Very itchy bullous or vesicular rash
 
* Typically starts periumbilically and spreads
 
* Starts in the second half of pregnancy, may flare post-partum
 
   
 
*Very itchy [[Bullous rash|bullous]] or [[vesicular rash]]
== Diagnosis ==
 
 
*Typically starts periumbilically and spreads
 
*Starts in the second half of pregnancy, may flare post-partum
   
 
==Diagnosis==
* Skin biopsy
 
   
 
*Skin biopsy
== Management ==
 
   
 
==Management==
* Prednisolone 0.5 mg/kg/d into the postpartum period, then titrate down
 
** May flare post-partum
 
* Second-line is azathioprine
 
   
 
*[[Is treated by::Prednisolone]] 0.5 mg/kg/d into the postpartum period, then titrate down
== Prognosis and Complications ==
 
 
**May flare post-partum
 
*Second-line is [[azathioprine]]
   
 
==Prognosis and Complications==
* 10% risk of neonatal pemphigoid
 
  +
* Associated with other autoimmune disorders
 
 
*10% risk of [[neonatal pemphigoid]]
 
*Associated with other autoimmune disorders
   
 
[[Category:Dermatology]]
 
[[Category:Dermatology]]

Latest revision as of 22:11, 2 August 2020

Background

Epidemiology

  • 1 in 50,000 pregnancies

Clinical Manifestations

  • Very itchy bullous or vesicular rash
  • Typically starts periumbilically and spreads
  • Starts in the second half of pregnancy, may flare post-partum

Diagnosis

  • Skin biopsy

Management

  • Prednisolone 0.5 mg/kg/d into the postpartum period, then titrate down
    • May flare post-partum
  • Second-line is azathioprine

Prognosis and Complications