Pediatric dosing of antimicrobials: Difference between revisions
From IDWiki
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| 400 mg/kg/day split q6h |
| 400 mg/kg/day split q6h |
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+ | |} |
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+ | |||
+ | === Cephalosporins === |
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+ | {| class="wikitable" |
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+ | ! Drug |
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+ | ! Indication |
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+ | ! Age |
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+ | ! Weight |
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+ | ! Usual dose |
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+ | |- |
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+ | ! colspan=5 | First generation |
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+ | |- |
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+ | | [[Cefazolin]] IV/IM |
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+ | | usual dose |
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+ | | colspan=2 | |
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+ | | 75-150 mg/kg/day split q8h (max 2 g/dose and 6 g/day) |
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+ | |- |
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+ | | rowspan=2 | [[Cephalexin]] PO |
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+ | | usual dose |
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+ | | colspan=2 | |
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+ | | 25-100 mg/kg/day split qid |
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+ | |- |
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+ | | osteomyelitis (oral step-down) |
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+ | | colspan=2 | |
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+ | | 100-150 mg/kg/day split qid |
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+ | |- |
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+ | ! colspan=5 | Second generation |
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+ | |- |
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+ | | [[Cefuroxime]] IV/IM |
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+ | | usual dose |
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+ | | colspan=2 | |
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+ | | 100-150 mg/kg/day split q8h (max 2 g/dose) |
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+ | |- |
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+ | | [[Cefuroxime]] azetil PO |
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+ | | colspan=3 | |
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+ | | poor bioavailability; not recommended |
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+ | |- |
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+ | | [[Cefprozil]] PO |
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+ | | usual dose |
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+ | | colspan=2 | |
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+ | | 15-30 mg/kg/day split bid (max 1 g/day) |
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+ | |- |
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+ | ! colspan=5 | Third generation |
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+ | |- |
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+ | | rowspan=6 | [[Cefotaxime]] IV/IM |
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+ | | rowspan=3 | usual dose |
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+ | | 0-7 days |
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+ | | |
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+ | | 50 mg/kg/dose q8h |
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+ | |- |
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+ | | >7 days |
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+ | | |
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+ | | 50 mg/kg/dose q8h |
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+ | |- |
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+ | | infants and children |
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+ | | |
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+ | | 100-200 mg/kg/day split q6-8h (max 6 g/day) |
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+ | |- |
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+ | | rowspan=3 | meningitis |
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+ | | 0-7 days |
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+ | | |
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+ | | 50 mg/kg/dose q8h |
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+ | |- |
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+ | | >7 days |
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+ | | |
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+ | | 50 mg/kg/dose q6h |
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+ | |- |
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+ | | infants and children |
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+ | | |
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+ | | 200-300 mg/kg/day split q6h (max 4 g/dose and 12 g/day) |
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+ | |- |
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+ | | rowspan=4 | [[Ceftriaxone]] IM/IV |
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+ | | usual dose |
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+ | | >1 month |
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+ | | |
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+ | | 50-75 mg/kg q24h (max 2 g/day) |
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+ | |- |
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+ | | meningitis |
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+ | | >1 month |
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+ | | |
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+ | | 100 mg/kg/day split q12-24h (max 2 g/dose and 4 g/day) |
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+ | |- |
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+ | | rowspan=2 | gonorrhea |
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+ | | ≥9 years |
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+ | | |
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+ | | 250 mg IM once |
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+ | |- |
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+ | | <9 years |
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+ | | |
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+ | | 50 mg/kg IM once (max 250 mg) |
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Revision as of 21:12, 17 November 2019
Antibiotics
Penicillins
Drug | Indication | Age | Weight | Usual dose |
---|---|---|---|---|
Penicillin G IV/IM | moderate to severe infections | 100,000 to 400,000 U/kg/day split q4-6h (max 24 MU/day) | ||
meningitis | 400,000 U/kg/day split q4h (max 24 MU/day) | |||
Penicillin VK PO | mild to moderate infections | 25-50 mg/kg/day split q8-12h | ||
rheumatic fever (treatment) | ≤ 27 kg | 300 mg PO bid x10 days | ||
> 27 kg | 600 mg PO bid x 10 days | |||
rheumatic fever (prophylaxis) | > 5 years | 300 mg PO bid | ||
asplenia (prophylaxis) | 6 months to 5 years | 150 mg PO bid | ||
> 5 years | 300 mg PO bid | |||
Cloxacillin IV | methicillin-susceptible Staphylococcus aureus | 100-200 mg/kg/day split q4-6h (max 2g/dose and 12 g/day) | ||
Cloxacillin PO | use cephalexin instead | |||
Ampicillin IV | usual dose | neonates | 100-200 mg/kg/day split q6-8h | |
infants and children | 100-200 mg/kg/day split q6h (max 2 g/dose) | |||
meningitis | neonates | 300 mg/kg/day split q6-8h | ||
infants and children | 300-400 mg/kg/day split q4-6h (max 2 g/dose) | |||
Amoxicillin PO | usual dose | 40-50 mg/kg/day split q8h | ||
Streptococcus pneumoniae | 80-90 mg/kg/day split q8h | |||
Group A Streptococcus pharyngitis | 50 mg/kg once daily x10 days (max 1 g/dose) | |||
Amoxicillin-clavulanic acid PO | usual dose | 30-50 mg/kg/day (amox component) split q8-12h (max 875 mg/dose) | ||
Streptococcus pneumoniae | 80-90 mg/kg/day (amox component) split q8-12h (max 875 mg/dose) | |||
Piperacillin-tazobactam IV | usual dose | 240-300 mg/kg/day (pip component) split q6-8h | ||
Pseudomonas aeruginosa or cystic fibrosis | 400 mg/kg/day split q6h |
Cephalosporins
Drug | Indication | Age | Weight | Usual dose |
---|---|---|---|---|
First generation | ||||
Cefazolin IV/IM | usual dose | 75-150 mg/kg/day split q8h (max 2 g/dose and 6 g/day) | ||
Cephalexin PO | usual dose | 25-100 mg/kg/day split qid | ||
osteomyelitis (oral step-down) | 100-150 mg/kg/day split qid | |||
Second generation | ||||
Cefuroxime IV/IM | usual dose | 100-150 mg/kg/day split q8h (max 2 g/dose) | ||
Cefuroxime azetil PO | poor bioavailability; not recommended | |||
Cefprozil PO | usual dose | 15-30 mg/kg/day split bid (max 1 g/day) | ||
Third generation | ||||
Cefotaxime IV/IM | usual dose | 0-7 days | 50 mg/kg/dose q8h | |
>7 days | 50 mg/kg/dose q8h | |||
infants and children | 100-200 mg/kg/day split q6-8h (max 6 g/day) | |||
meningitis | 0-7 days | 50 mg/kg/dose q8h | ||
>7 days | 50 mg/kg/dose q6h | |||
infants and children | 200-300 mg/kg/day split q6h (max 4 g/dose and 12 g/day) | |||
Ceftriaxone IM/IV | usual dose | >1 month | 50-75 mg/kg q24h (max 2 g/day) | |
meningitis | >1 month | 100 mg/kg/day split q12-24h (max 2 g/dose and 4 g/day) | ||
gonorrhea | ≥9 years | 250 mg IM once | ||
<9 years | 50 mg/kg IM once (max 250 mg) |