Pancytopenia

Differential Diagnosis

• Decreased production
  • Infection
    • Viral infection
      • Epstein-Barr virus
      • Parvovirus B19
      • Cytomegalovirus, if immunocompromised
      • Human immunodeficiency virus
      • Dengue virus
      • Viral hepatitis
    • Other
      • Leptospirosis
  • Malignancy
    • Hematologic malignancy
    • Solid-organ malignancy
      • Metastases
  • Other
    • Sarcoidosis
    • Amyloidosis
  • Systemic
    • Vitamin B12 deficiency
• Increased destruction
• Sequestration

Clinical Manifestations

• Increased infections
• Bleeding
• Angina and other hypoxemic symptoms