Pancytopenia: Difference between revisions

Revision as of 15:22, 13 September 2020

Clinical Manifestations

Increased infections
Bleeding
Angina and other hypoxemic symptoms

Differential Diagnosis

See also aplastic anemia
Decreased production
- Infection
  - Viral
    - Epstein-Barr virus: chronic active EBV and primary infection that results in hemophagocytic lymphohistiocytosis
    - Parvovirus B19: usually transient, but can also cause pure red cell aplasia
    - Cytomegalovirus, if immunocompromised
    - Hepatitis A virus
    - Human immunodeficiency virus
    - Dengue virus
  - Bacterial
    - Mycobacterium tuberculosis, in the context of disseminated disease
    - Leptospira species
    - Brucella species
    - Bartonella henselae and Bartonella quintana, causing bacillary angiomatosis involving liver and spleen
    - Mycoplasma pneumoniae, associated with fulminant infection and the presence of cold agglutinin disease
    - Ehrlichia chaffeensis, causing hemophagocytic lymphohistiocytosis
  - Fungal
    - Pneumocystis jirovecii, from bone marrow necrosis
  - Parasitic
    - Visceral leishmaniasis
- Malignancy
  - Hematologic malignancy
  - Solid organ malignancy
    - Metastases
- Other
  - Sarcoidosis
  - Amyloidosis
- Systemic
  - Vitamin B12 deficiency
Increased destruction
Sequestration
Drug-related
- Linezolid
- Coadministration of TMP-SMX and methotrexate

@@ Line 1: / Line 1: @@
+==Clinical Manifestations==
-==Differential Diagnosis==
+*Increased infections
+*Bleeding
+*Angina and other hypoxemic symptoms
+== Differential Diagnosis ==
+*See also [[aplastic anemia]]
 *Decreased production
 **Infection
-***Viral infection
+***Viral
-****[[Epstein-Barr virus]]
+****[[Epstein-Barr virus]]: chronic active EBV and primary infection that results in [[hemophagocytic lymphohistiocytosis]]
-****[[Parvovirus B19]]
+****[[Parvovirus B19]]: usually transient, but can also cause pure red cell aplasia
 ****[[Cytomegalovirus]], if immunocompromised
+****[[Hepatitis A virus]]
 ****[[Human immunodeficiency virus]]
 ****[[Dengue virus]]
+***Bacterial
-****[[Viral hepatitis]]
+****[[Mycobacterium tuberculosis]], in the context of disseminated disease
-***Other
-****[[Leptospirosis]]
+****[[Leptospira species]]
+****[[Brucella species]]
+****[[Bartonella henselae]] and [[Bartonella quintana]], causing [[bacillary angiomatosis]] involving liver and spleen
+****[[Mycoplasma pneumoniae]], associated with fulminant infection and the presence of cold agglutinin disease
+****[[Ehrlichia chaffeensis]], causing [[hemophagocytic lymphohistiocytosis]]
+***Fungal
+****[[Pneumocystis jirovecii]], from bone marrow necrosis
+***Parasitic
+****[[Visceral leishmaniasis]]
 **Malignancy
 ***[[Hematologic malignancy]]
@@ Line 23: / Line 39: @@
 *Increased destruction
 *Sequestration
+*Drug-related
+**Linezolid
-==Clinical Manifestations==
+**Coadministration of [[TMP-SMX]] and [[methotrexate]]
-*Increased infections
-*Bleeding
-*Angina and other hypoxemic symptoms
 [[Category:Hematology]]