Multidrug-resistant Gram-negative bacteria

Management

• Ceftolozane-tazobactam (Zerbaxa)
  • May be better for multidrug-resistance Pseudomonas (or at least more experience with it)
• Ceftazidime-avibactam: available through Special Access Program
  • Adds coverage of some carbapenemases and AmpC
• Fosfomycin
• Colistin
• Cefiderocol: available through Special Access Program as well as preapproval by manufacturer
• Meropenem-vaborbactam: still awaiting Health Canada Drug Review
• Imipenem-relebactam (really imipenem-cilastatin-relebactam): still awaiting Health Canada Drug Review