Isavuconazole: Difference between revisions
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=== Spectrum of Activity === |
=== Spectrum of Activity === |
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| − | *Active against [[Candida]], [[Cryptococcus]], [[Aspergillus |
+ | *Active against [[Candida]], [[Cryptococcus]], [[Aspergillus]] including [[Aspergillus flavus]], [[Aspergillus fumigatus]], and [[Aspergillus niger]], and [[Mucorales]] |
*Indications include {{#ask: [[Is treated by::isavuconazole]]}} |
*Indications include {{#ask: [[Is treated by::isavuconazole]]}} |
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Revision as of 16:52, 27 January 2022
Background
Mechanism of Action
- Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway
Spectrum of Activity
- Active against Candida, Cryptococcus, Aspergillus including Aspergillus flavus, Aspergillus fumigatus, and Aspergillus niger, and Mucorales
- Indications include Chromoblastomycosis, Cladophialophora, Coccidioides immitis
Dosing
- Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily
Renal Dosing
- No adjustment needed
Hepatic Dosing
- No adjustment needed
Safety
Adverse Drug Reactions
- Nausea, vomiting, diarrhea
- Elevated liver enzymes
- Hypokalemia
Drug-Drug Interactions
- Increases levels of sirolimus and tacrolimus
- Increases levels of cyclosporine
- Contraindicated with carbamazepine
