Interstitial nephritis

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Etiology

Drugs

Infections

Autoimmune Disorders

Clinical Manifestations

  • Can be asymptomatic, presenting with renal dysfunction
  • Nausea, vomiting, malaise, and oliguria
  • May have arthralgias
  • With drug-induced AIN, can have an allergic syndrome that includes fever, eosinophilia, and rash

Investigations

  • Creatinine, showing AKI
  • CBC, showing eosinophilia
  • Urine studies
    • May have pyuria and white cell casts and RBCs, and eosinophiluria
    • Usually around 1 g/day of proteinuria
    • FENa >1%