Interstitial lung disease: Difference between revisions

Latest revision as of 11:56, 18 February 2023

Differential Diagnosis

Primary
- IPF
- COP
- NSIP
Secondary
- Inflammatory or connective tissue diseases
- Exposures
  - Hypersensitivity pneumonitis
  - Drugs: nitrofurantoin, chemotherapy (cyclophosphamide, bleomycin), methotrexate, amiodarone
  - Inorganic exposures: silicosis and asbestosis
  - Occupational and hobby exposures
    - Hypersensitivity pneumonitis, including bird fancier's lung, cheese-washer's lung, farmer's lung
    - Hot tub lung (Mycobacterium avium)
  - Radiation pneumonitis
Mimickers
- Congestive heart failure
- Interstitial infections
  - Pneumocystis jirovecii pneumonia
  - Mycoplasma
  - Legionella
  - Viral pneumonia
- Lymphangitic carcinomatosis

By Location Predominance

Upper Lobe Predominance (HASTEN)

Hypersensitivity pneumonitis
Ankylosing spondylitis
Sarcoidosis and silicosis
Tuberculosis, viral pneumonia, Mycoplasma
Eosinophilic granulomas (aka pulmonary Langerhan cell histiocytosis, present with spontaneous pneumothorax)
Neurofibromatosis

Lower Lobe Predominance (BAD RASH)

Bleomycin
Amiodarone
Drugs: nitrofurantoin, cyclophosphamide, methotrexate
Rheumatoid lung
Asbestosis
Scleroderma
Hamman-Rich syndrome (aka acute interstitial pneumonia = rare, fulminant form of IPF)

@@ Line 2: / Line 2: @@
 * Primary
-** IPF
+** [[IPF]]
-** COP
+** [[COP]]
-** NSIP
+** [[NSIP]]
 * Secondary
 ** Inflammatory or connective tissue diseases
-*** Rheumatoid arthritis
+*** [[Rheumatoid arthritis]]
-*** Systemic lupus erythematosus
+*** [[Systemic lupus erythematosus]]
-*** Dermatomyositis
+*** [[Dermatomyositis]]
-*** Systemic sclerosis
+*** [[Systemic sclerosis]]
-*** Sarcoidosis
+*** [[Sarcoidosis]]
 ** Exposures
-*** Hypersensitivity pneumonitis
+*** [[Hypersensitivity pneumonitis]]
+*** Drugs: [[nitrofurantoin]], chemotherapy ([[cyclophosphamide]], [[bleomycin]]), [[methotrexate]], [[amiodarone]]
-*** Inorganic
+*** Inorganic exposures: [[silicosis]] and [[asbestosis]]
-**** Silica
+*** Occupational and hobby exposures
-**** Asbestos
+**** [[Hypersensitivity pneumonitis]], including bird fancier's lung, cheese-washer's lung, farmer's lung
-*** Drugs
-**** [[Nitrofurantoin]]
+**** Hot tub lung ([[Mycobacterium avium]])
+*** [[Radiation pneumonitis]]
-**** Chemotherapy
-***** Cyclophosphamide
-***** Others
-**** Methotrexate
-*** Organic
-**** Occupational and hobby lung diseases
-*** Radiation pneumonitis
 * Mimickers
-** Congestive heart failure
+** [[Congestive heart failure]]
 ** Interstitial infections
 *** [[Pneumocystis jirovecii pneumonia]]
@@ Line 33: / Line 27: @@
 *** [[Legionella]]
 *** Viral pneumonia
-** Lymphangitic carcinomatosis
+** [[Lymphangitic carcinomatosis]]
+=== By Location Predominance ===
+==== Upper Lobe Predominance (HASTEN) ====
+* [[Hypersensitivity pneumonitis]]
+* [[Ankylosing spondylitis]]
+* [[Sarcoidosis]] and [[silicosis]]
+* [[Tuberculosis]], viral pneumonia, [[Mycoplasma]]
+* Eosinophilic granulomas (aka pulmonary [[Langerhan cell histiocytosis]], present with spontaneous pneumothorax)
+* [[Neurofibromatosis]]
+==== Lower Lobe Predominance (BAD RASH) ====
+* [[Bleomycin]]
+* [[Amiodarone]]
+* Drugs: [[nitrofurantoin]], [[cyclophosphamide]], [[methotrexate]]
+* [[Rheumatoid lung]]
+* [[Asbestosis]]
+* [[Scleroderma]]
+* [[Hamman-Rich syndrome]] (aka [[acute interstitial pneumonia]] = rare, fulminant form of IPF)
 [[Category:Respirology]]