Grover disease: Difference between revisions

Revision as of 11:18, 27 September 2023

Self-limited, papulovesicular rash, most common in older shite men
Lesions are usually pruritis
Can form crusts and keratotic erosions
Affects trunk almost universally, but can also involve proximal and lower extremities, and, occasionally, neck and face
Self-resolves over weeks to months, but occasionally can have a chronic fluctuating course lasting years
- Can recur seasonally in winter and summer

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+== Background ==
-* Papular erythematous rash with erosions that usually follows sweating or heat exposure in older men, often itchy
-* Rarely neoplastic
+* Also known as '''transient acantholytic dermatosis'''
+* Risk factors
+** Almost always in men
+** Heat and sweating, but also cold, dry air in winder
+** Chronic kidney disease
+** Induction chemotherapy for transplantation
+** Drugs, including [[sulfadoxine-pyrimethamine]], [[recombinant IL-4]], [[BRAF inhibitor]], [[ipilimumab]], and other [[immune checkpoint inhibitors]]
+** Rarely neoplastic
+== Clinical Manifestations ==
+* Self-limited, papulovesicular rash, most common in older shite men
+* Lesions are usually pruritis
+* Can form crusts and keratotic erosions
+* Affects trunk almost universally, but can also involve proximal and lower extremities, and, occasionally, neck and face
+* Self-resolves over weeks to months, but occasionally can have a chronic fluctuating course lasting years
+** Can recur seasonally in winter and summer
+== Differential Diagnosis ==
+* [[Eczema]], [[contact dermatitis]], [[atopic dermatitis]]
+== Further Reading ==
+* Aldana PC, Khachemoune A. Grover disease: review of subtypes with a focus on management options. ''Int J Dermatol''. 2020 May;59(5):543-550. doi: [https://doi.org/10.1111/ijd.14700 10.1111/ijd.14700]. PMID: [https://pubmed.ncbi.nlm.nih.gov/31724740/ 31724740].
 [[Category:Dermatology]]