Fluconazole: Difference between revisions

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(added breakpoints table)
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*Fungistatic
  
*Fungistatic
 
*Efficacy predicted by AUC/MIC ratio
  
*Efficacy predicted by AUC/MIC ratio
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−
*Susceptibility breakpoints for [[Candida albicans]] are:
  
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{| class="wikitable"
−
**Susceptible MIC ≤2
  
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! rowspan="2" |Species
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**Susceptible dose-dependent MIC 4
  
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! colspan="4" |Breakpoints (μg/mL)
−
**Resistant MIC ≥8
  
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! colspan="4" |Breakpoints (mm)
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|-
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!S
  +
!I
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!SDD
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!R
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!S
  +
!I
  +
!SDD
  +
!R
  +
|-
  +
|[[Candida albicans]]
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|≤2
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|—
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|4
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|≥8
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|≥17
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|—
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|14-16
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|≤13
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|-
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|[[Candida glabrata]]
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|—
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|—
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|≤32
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|≥64
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|—
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|—
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|≥15
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|≤14
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|-
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|[[Candida krusei]]
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| colspan="4" |intrinsically resistant
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| colspan="4" |intrinsically resistant
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|-
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|[[Candida parapsilosis]]
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|≤2
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|—
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|4
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|≥8
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|≥17
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|—
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|14-16
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|≤13
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|-
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|[[Candida tropicalis]]
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|≤2
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|—
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|4
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|≥8
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|≥17
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|—
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|14-16
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|≤13
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|}
   
 
==Monitoring==
  
==Monitoring==

Revision as of 16:26, 21 August 2020

Background

  • Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida

Pharmacokinetics and Pharmacodynamics

  • Good oral bioavailability
  • Good CNS penetration
  • Fungistatic
  • Efficacy predicted by AUC/MIC ratio
Species Breakpoints (μg/mL) Breakpoints (mm)
S I SDD R S I SDD R
Candida albicans ≤2 — 4 ≥8 ≥17 — 14-16 ≤13
Candida glabrata — — ≤32 ≥64 — — ≥15 ≤14
Candida krusei intrinsically resistant intrinsically resistant
Candida parapsilosis ≤2 — 4 ≥8 ≥17 — 14-16 ≤13
Candida tropicalis ≤2 — 4 ≥8 ≥17 — 14-16 ≤13

Monitoring

  • ECG for QT prolongation
  • Liver enzymes for hepatitis

Adverse Drug Reactions

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