Erythema nodosum: Difference between revisions

Latest revision as of 16:09, 2 August 2020

Background

Pathophysiology

Delayed hypersensitivity reaction causing a septal panniculitis without vasculitis

Clinical Manifestations

Erythematous, tender nodules on the shins

Differential Diagnosis

Infections
- Bacterial
  - Streptococcal infection (the most common infectious cause)
  - Tuberculosis
  - Leprosy
  - Yersinia, Salmonella, Campylobacter gastroenteritis
  - Mycoplasma pneumoniae
  - Tularemia
  - Leptospirosis
  - Brucellosis
  - Chlamydia trachomatis
  - Psittacosis
  - Lymphogranuloma venereum
  - Cat-scratch disease
- Fungal
- Viral
Drugs
- Oral contraceptives
- Penicillin
- Sulfonamides
- Bromides and iodides
- TNF-α inhibitors (rare)
Inflammatory bowel disease
- Crohn disease (more often than ulcerative colitis)
- Ulcerative colitis
Malignancy
- Lymphoma (Hodgkin, most often)
- Leukemia (acute myelogenous, most often)
- Internal carcinomas
Miscellaneous

@@ Line 1: / Line 1: @@
-== Differential Diagnosis ==
+== Background ==
+=== Pathophysiology ===
-* Infections
-** Bacterial
+* Delayed hypersensitivity reaction causing a septal panniculitis without vasculitis
-*** Streptococcal infection (the most common infectious cause)
-*** Tuberculosis
+== Clinical Manifestations ==
-*** Leprosy
-*** Yersinia, Salmonella, Campylobacter gastroenteritis
+* Erythematous, tender nodules on the shins
-*** Mycoplasma pneumonia
-*** Tularemia
+==Differential Diagnosis==
-*** Leptospirosis
-*** Brucellosis
+*Infections
-*** Chlamydia trachomatis
+**Bacterial
-*** Psittacosis
+***[[Streptococcus species|Streptococcal infection]] (the most common infectious cause)
-*** Lymphogranuloma venereum
+***[[Tuberculosis]]
-*** Cat-scratch disease
+***[[Leprosy]]
-** Fungal
+***[[Yersinia]], [[Salmonella]], [[Campylobacter]] gastroenteritis
-*** Coccidioidomycosis
+***[[Mycoplasma pneumoniae]]
-*** Histoplasmosis
+***[[Tularemia]]
-*** Blastomycosis
+***[[Leptospirosis]]
-** Viral
+***[[Brucellosis]]
-*** Infectious mononucleosis
+***[[Chlamydia trachomatis]]
-*** Hepatitis B
+***[[Psittacosis]]
-*** Paravaccinia
+***[[Lymphogranuloma venereum]]
-* Drugs
+***[[Cat-scratch disease]]
-** Oral contraceptives
+**Fungal
-** Penicillin
+***[[Coccidioidomycosis]]
-** Sulfonamides
+***[[Histoplasmosis]]
-** Bromides and iodides
+***[[Blastomycosis]]
-** TNF-alpha inhibitors (rare)
+**Viral
-* Inflammatory bowel disease
+***[[Infectious mononucleosis]]
-** Crohn's disease (more often than ulcerative colitis)
+***[[Hepatitis B]]
-** Ulcerative colitis
+***[[Paravaccinia]]
-* Malignancy
+*Drugs
-** Lymphoma (Hodgkin, most often)
+**[[Oral contraceptive|Oral contraceptives]]
-** Leukemia (acute myelogenous, most often)
+**[[Penicillin]]
-** Internal carcinomas
+**[[Sulfonamide|Sulfonamides]]
-* Miscellaneous
+**[[Bromide|Bromides]] and [[Iodide|iodides]]
-** Sarcoidosis
+**[[TNF-α inhibitor|TNF-α inhibitors]] (rare)
-** Pregnancy
-** Whipple disease
+*[[Inflammatory bowel disease]]
+**[[Crohn disease]] (more often than ulcerative colitis)
-** Behçet disease
+**[[Ulcerative colitis]]
-** Sweet syndrome
+*Malignancy
+**[[Lymphoma]] ([[Hodgkin lymphoma|Hodgkin]], most often)
+**[[Leukemia]] ([[Acute myelogenous leukemia|acute myelogenous]], most often)
+**Internal [[Carcinoma|carcinomas]]
+*Miscellaneous
+**[[Sarcoidosis]]
+**[[Pregnancy]]
+**[[Whipple disease]]
+**[[Behçet disease]]
+**[[Sweet syndrome]]
 [[Category:Clinical exam]]