Eosinophilia: Difference between revisions
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| + | == Background == |
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| + | * Any eosinophil count over 0.5 |
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| + | * May be primary (either eosinophilic hematologic malignancy or idiopathic) or secondary/reactive |
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==Differential Diagnosis== |
==Differential Diagnosis== |
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**Parasitic infections including [[Strongyloides stercoralis]], [[hookworms]], [[schistosomiasis]], and [[scabies]] |
**Parasitic infections including [[Strongyloides stercoralis]], [[hookworms]], [[schistosomiasis]], and [[scabies]] |
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**[[Tropical pulmonary eosinophilia]] from filarial roundworms ([[Wuchereria bancrofti]] and [[Brugia]]) |
**[[Tropical pulmonary eosinophilia]] from filarial roundworms ([[Wuchereria bancrofti]] and [[Brugia]]) |
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| + | **Can also be seen with other [[Helminth|helminths]], [[HIV]], [[HTLV]], [[Borrelia]], and [[Aspergillus]] |
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*Inflammatory |
*Inflammatory |
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**[[Eosinophilic pneumonia]] |
**[[Eosinophilic pneumonia]] |
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**[[Atopy]] |
**[[Atopy]] |
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**[[Asthma]] |
**[[Asthma]] |
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| − | *Drugs |
+ | **Drugs |
| + | ***[[Hypersensitivity reaction]] to [[NSAID|NSAIDs]], [[Antibiotic|antibiotics]], [[allopurinol]], [[Aromatic anticonvulsant|aromatic anticonvulsants]], [[sulfasalazine]], [[TMP-SMX]], [[PPI|PPIs]], [[vancomycin]] |
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| − | **[[Drug reaction with eosinophilia and systemic symptoms]] (DRESS) |
+ | ***[[Drug reaction with eosinophilia and systemic symptoms]] (DRESS) |
==Investigations== |
==Investigations== |
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Revision as of 09:54, 21 February 2022
Background
- Any eosinophil count over 0.5
- May be primary (either eosinophilic hematologic malignancy or idiopathic) or secondary/reactive
Differential Diagnosis
- Hematologic
- Primary: eosinophilic leukemia, CMML, hypereosinophilic syndrome
- Secondary: Non-Hodgkin lymphoma and Hodgkin lymphoma
- Infectious
- Parasitic infections including Strongyloides stercoralis, hookworms, schistosomiasis, and scabies
- Tropical pulmonary eosinophilia from filarial roundworms (Wuchereria bancrofti and Brugia)
- Can also be seen with other helminths, HIV, HTLV, Borrelia, and Aspergillus
- Inflammatory
- Endocrine
- Allergy
Investigations
- CBC
- Stool for ova and parasites (specifically for helminths rather than protozoa)
- Strongyloides serology, +/- Schistosoma serology
- ANCAs
- Review current medications
