Cefuroxime: Difference between revisions
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(Created page with "== Background == * Second-generation cephalosporin * Spectrum includes MSSA, streptococci, Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningi...") |
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* Second-generation [[Cephalosporins|cephalosporin]] |
* Second-generation [[Cephalosporins|cephalosporin]] |
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| − | * Spectrum includes MSSA, streptococci, Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitides, Neisseria gonorrhoeae, and Escherichia coli |
+ | * Spectrum includes [[MSSA]], [[streptococci]], [[Haemophilus influenzae]], [[Moraxella catarrhalis]], [[Neisseria meningitides]], [[Neisseria gonorrhoeae]], and [[Escherichia coli]] |
* Time-dependent killing |
* Time-dependent killing |
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* Time to peak 3 hours, elimination half-life 1.2 hours |
* Time to peak 3 hours, elimination half-life 1.2 hours |
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* AECOPD: 250 to 500 mg PO q12h for 10 days |
* AECOPD: 250 to 500 mg PO q12h for 10 days |
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* Uncomplicated UTI: 125 to 250 mg PO q12h for 7 to 10 days |
* Uncomplicated UTI: 125 to 250 mg PO q12h for 7 to 10 days |
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| − | * Gonorrhea: 1 g PO once |
+ | * [[Gonorrhea]]: 1 g PO once |
* Pneumonia: 750 to 1500 mg IV/IM q8h |
* Pneumonia: 750 to 1500 mg IV/IM q8h |
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* Bone or joint infection: 1.5 g IV/IM q8h |
* Bone or joint infection: 1.5 g IV/IM q8h |
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Latest revision as of 15:09, 31 January 2024
Background
- Second-generation cephalosporin
- Spectrum includes MSSA, streptococci, Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitides, Neisseria gonorrhoeae, and Escherichia coli
- Time-dependent killing
- Time to peak 3 hours, elimination half-life 1.2 hours
Dosing
- Typical dose: 250 to 500 mg PO q12h
- AECOPD: 250 to 500 mg PO q12h for 10 days
- Uncomplicated UTI: 125 to 250 mg PO q12h for 7 to 10 days
- Gonorrhea: 1 g PO once
- Pneumonia: 750 to 1500 mg IV/IM q8h
- Bone or joint infection: 1.5 g IV/IM q8h
