Antifungals: Difference between revisions

Latest revision as of 22:48, 7 February 2022

Polyenes

Mechanism: bind to ergosterol in the cell membrane and create pores
Examples: Amphotericin B

Triazoles

Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
Examples
- Fluconazole: Used as prophylaxis or treatment for Candida
- Voriconazole: First-line treatment for invasive aspergillosis
- Itraconazole
- Posaconazole: Second-line treatment for invasive aspergillosis, but first-line for prophylaxis
- Isavuconazole

Echinocandins

Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
Examples
- Micafungin
- Caspofungin: Febrile neutropenia
- Anidulafungin: ICU (high APACHEII), no renal or hepatic dosing needed

@@ Line 1: / Line 1: @@
+See also [[Antifungal spectrum of activity]]
-= Antifungals =
+==Polyenes==
-See also [Antifungal spectrum](Antifungal spectrum.md)
+*Mechanism: bind to ergosterol in the cell membrane and create pores
-== Polyenes ==
+*Examples: [[Amphotericin B]]
+==Triazoles==
-* Mechanism: bind to ergosterol in the cell membrane and create pores
-* Examples: Amphotericin B
+*Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
-== Triazoles ==
+*Examples
+**[[Fluconazole]]: Used as prophylaxis or treatment for [[Candida]]
+**[[Voriconazole]]: First-line treatment for [[invasive aspergillosis]]
+**[[Itraconazole]]
+**[[Posaconazole]]: Second-line treatment for [[invasive aspergillosis]], but first-line for prophylaxis
+**[[Isavuconazole]]
+==Echinocandins==
-* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
-* Examples
-** Fluconazole: Used as aspergillosis prophylaxis
-** Voriconazole: First line treatment for invasive aspergillosis
-** Posaconazole: Second line treatment for invasive aspergillosis
-*** Does not require adjustment in hepatic disease?
+*Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
-== Echinocandins ==
+*Examples
+**[[Micafungin]]
+**[[Caspofungin]]: Febrile neutropenia
+**[[Anidulafungin]]: ICU (high APACHEII), no renal or hepatic dosing needed
+[[Category:Antimicrobials]]
-* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
-* Examples
-** Micafungin
-** Caspofungin: Febrile neutropenia
-** Anidulafungin: ICU (high APACHEII), no renal or hepatic dosing needed