| Species | Disease | Vector | Reservoir | Notes |
|---|---|---|---|---|
| Borrelia burgdorferi | European and North American Lyme disease | Ixodes scapularis (northeastern/midwestern USA) Ixodes pacificus (western USA) ticks | rodents and deer | more joint involvement |
| Borrelia afzelii | European Lyme disease | Ixodes ricinus in Europe and Ixodes persulcatus in Asia | most common in Europe; more skin manifestations | |
| Borrelia garinii | most common in Europe and Asia; more neurotropic | |||
| Borrelia spielmanii | ||||
| Borrelia bavariensis | ||||
| Borrelia recurrentis | louse-borne relapsing fever | Pediculus humanus humanus body louse | humans | |
| Borrelia hermsii | tick-borne relapsing fever | Ornithodoros hermsii ticks | rodents | |
| Borrelia turicatae | Ornithodoros turicata ticks | rodents | ||
| Borrelia parkeri | Ornithodoros parkeri ticks | rodents | ||
| Borrelia mazzottii | Ornithodoros talaje ticks | rodents | ||
| Borrelia venezuelensis | Ornithodoros rudis ticks | rodents | ||
| Borrelia crocidurae | Ornithodoros erraticus ticks | rodents | ||
| Borrelia hispanica | Ornithodoros maracanus ticks |
