Clostridial toxic shock syndrome
From IDWiki
Background
- Toxic shock syndrome caused by Clostridium sordellii
Clinical Manifestations
- Hemoconcentration with high hematocrit and hemoglobin
- Capillary leak causing edema and ascites
- Leukemoid reaction
- Often afebrile
Management
- Fluid resuscitation
- Penicillin G 18-20 million units daily divided q4-6h
- Plus clindamycin 900 mg IV q8h for toxin production
