γ-glutamyltransferase

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Γ-glutamyltransferase


Interpretation

  • About 90% sensitive for cholestasis (with ALP)
  • Isolated elevation of GGT may be caused by enzyme induction from alcohol or aromatic medications, without liver disease1
    • Aromatic medications include, commonly, phenobarbital, phenytoin, and others
    • Elevation is usually about twice the upper limit of normal

References

  1. ^ PMID10221307 
  2. ^  E. G. Giannini. Liver enzyme alteration: a guide for clinicians. Canadian Medical Association Journal. 2005;172(3):367-379. doi:10.1503/cmaj.1040752.