γ-glutamyltransferase

From IDWiki
Γ-glutamyltransferase


Background

  • Liver enzyme in microsomes that catalyzes transfer of γ-glutamyl group from peptides to other amino acids

Interpretation

  • About 90% sensitive for cholestasis (with ALP)
    • Often only rise after several days
  • Isolated elevation of GGT may be caused by enzyme induction from alcohol or aromatic medications, without liver disease1
    • Aromatic medications include, commonly, phenobarbital, phenytoin, and others
    • Elevation is usually about twice the upper limit of normal
  • Can also see isolated elevations in COPD, AKI or CKD, and acute myocardial infarction2
  • May be elevated in NAFLD and hepatitis C and other liver or biliary diseases

References

  1. ^ PMID10221307 
  2. ^ giannini2005li