Dapsone
From IDWiki
Background
- Diamino-diphenyl sulfone
Indications
- Second-line PJP prophylaxis (CD4 <200)
- Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae
Dosing
- Dermatitis herpetiformis: Start at 50 mg PO daily, increase to 300 mg daily, or higher to achieve full control, reduce to minimum maintenance dosage as soon as possible
- PJP prophylaxis (primary or secondary):
- 100 mg PO once daily or in 2 divided doses as monotherapy
- Continue until CD4 count >200 cells/mm3 for >3 months
- PJP treatment: 100 mg PO once daily in combination with trimethoprim for 21 days
