Acquired immunodeficiency

Differential Diagnosis

Cell-Mediated Immunodeficiency

• Corticosteroids
• Solid organ transplantation
• Hematologic malignancy
  • Hairy cell leukemia
  • Acute T-cell leukemia
  • T-cell lymphoma
• Chemotherapy
  • Fludarabine
  • Ibrutinib
  • Alemtuzumab

Humoural Immunodeficiency

• Splenectomy and asplenism
• Complement deficiency
• Common variable immunodeficiency
• Rituximab and other anti-CD20 therapy
• Multiple myeloma and chronic lymphocytic leukemia

Phagocyte Immunodeficiency

• Corticosteroids
• Solid organ transplantation
• Neutropenia
• Myelodysplastic syndrome
• Acute myelogenous leukemia
• Allogeneic hematopoietic stem cell transplantation