Amphotericin B
From IDWiki
- Last choice of antifungal due to side effect profile, but effective
- Binds to ergosterol in fungal cell membrane and creates pores that cause leakage of monovalent ions
- Causes renal dysfunction, among other things
Clinical Breakpoints
| Species | ECV (μg/mL) | Breakpoints (μg/mL) | Breakpoints (mm) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| S | SDD | I | R | S | SDD | I | R | ||
| Candida albicans | 2 | ||||||||
| Candida dubliniensis | |||||||||
| Candida glabrata | 2 | ||||||||
| Candida guilliermondii | |||||||||
| Candida krusei | 2 | ||||||||
| Candida lusitaniae | |||||||||
| Candida parapsilosis | 2 | ||||||||
| Candida tropicalis | 2 | ||||||||
| Cryptococcus neoformans | 0.5 | ||||||||
| Cryptococcus gattii | 0.5-1 | ||||||||
| Aspergillus flavus | 4 | ||||||||
| Aspergillus fumigatus | 2 | ||||||||
| Aspergillus species | 2 | ||||||||
| Aspergillus species | 4 | ||||||||
| Aspergillus versicolor | 2 | ||||||||
