Antibiotic-associated diarrhea

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Differential Diagnosis

  • Clostridioides difficile
  • Other microbes: Clostridium perfringens type A (food poisoning), Staphylococcus aureus, Salmonella enterica, and possible Candida albicans
  • Direct effects on intestinal tract
    • Erythromycin and clavulanate cause increased motility
    • Penicillins may rarely cause a segmental colitis
  • Effects on the fecal microbiota
    • Decreased carbohydrate metabolism, leading to osmotic diarrhea
    • Breakdown of primary bile acids, leading to secretory diarrhea
  • Concomitant use of laxatives, antacids, contrast, lactose- or sorbitol-containing products, NSAIDs, antiarrhythmic drugs, and cholinergic drugs