Hemolytic-uremic syndrome
From IDWiki
Background
- Typical HUS is a Thrombotic microangiopathy with prominent renal failure traditionally associated with Shiga toxin-producing Escherichia coli infection, especially enterohemorrhagic E. coli O157:H7
- Difference pathophysiology and treatment from atypical hemolytic-uremic syndrome
Pathophysiology
- Typical HUS is caused by Shiga toxin from enterohemorrhagic Escherichia coli (e.g. O157:H7)
- Toxin is absorbed systemically, causing platelet activation and aggregation
Risk Factors
- Younger age
- Exposure to antibiotics
- Increased WBC count
- Vomiting
- Prolonged diarrhea
- Presence of stx2a and eae genes
Clinical Manifestations
- A few days of bloody diarrhea
- Progression of hemolytic anemia, thrombocytopenia, and severe AKI
Management
- Supportive
