Infective endocarditis

• Infection of heart valves

Organisms

• Bacteria
  • Staphylococcus aureus (most common)
  • Viridans group streptococci
  • Coagulase-negative Staphylococci
  • Other streptococci
  • Enterococci
  • HACEK group
  • Coxiella
  • Brucella
• Fungi
  • Candida

Presentation

• Modified Duke criteria
• IVDU: Viridans group streptococci and Pseudomonas aeroginosa
• Colon cancer: Streptococcus bovis and Clostridium septicum

Treatment

• MSSA native valve endocarditis
  • Cloxacillin or cefazolin
  • OR Vancomycin/Daptomycin
• MSSA prosthetic valve endocarditis
  • Cloxacillin PLUS rifampin PLUS 2 weeks of gentamicin
  • OR Vancomycin/Daptomycin, other things
• 6 weeks