Toxic shock syndrome
From IDWiki
- Severe septic shock caused by certain bacterial infections
- Caused by superantigens, which non-specifically activate T-cells
Criteria | Staphylococcal | Streptococcal |
---|---|---|
Confirmed | hypotension + fever + rash + desquamating + 3 or more other | hypotension + 2 or more other |
Hypotension | SBP ≤90 mmHg | SBP ≤90 mmHg |
Fever | temp ≥38.9ºC | |
Skin | diffuse macular erythroderma followed by desquamation | generalized erythematous macular rash that may desquamate |
GI | n/v/d at onset | |
Resp | ARDS | |
MSK | myalgia ± CK ≥2x ULN | soft-tissue necrosis (e.g. nec.fasc) |
Mucosa | hyperemia of any mucosa | |
Nephro | Creatinine ≥2x ULN, or pyuria without UTI |
Creatinine ≥177 or ≥2x ULN or ≥2x baseline |
Hepatic | bili/ALT/AST ≥2x ULN | ALT/AST/bili ≥2x ULN or ≥2x baseline |
Heme | thrombocytopenia <100 | thrombocytopenia ≤100, or DIC (INR/fibrinogen/D-dimer) |
CNS | altered LOC without focal signs |