Smudge cells

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Background

  • Also called basket cells or Gumprecht shadows
  • Remnants of fragile leukocytes that are smeared during preparation of a blood film

Differential Diagnosis

  • Classically associated with CLL, where they represent ruptured diseased B cells
  • May also be seen in some infections (including infectious mononucleosis), post-cardiac arrest, inflammatory conditions
    • Also solid-organ malignancies and artifact