Infective endocarditis

Diagnosis

• Infection of heart valves

Organisms

• Staphylococcus aureus
• Viridans group streptococci
• Coagulase-negative staphylococci
• Other streptococci
• Enterococci
• HACEK group
• Fungi

Presentation

• Modified Duke criteria
• IVDU: Viridans group streptococci and Pseudomonas aeroginosa
• Colon cancer: Streptococcus bovis and Clostridium septicum

Treatment

• MSSA native valve endocarditis
  • Cloxacillin or cefazolin
  • OR Vancomycin/Daptomycin
• MSSA prosthetic valve endocarditis
  • Cloxacillin PLUS rifampin PLUS 2 weeks of gentamicin
  • OR Vancomycin/Daptomycin, other things
• 6 weeks