β-lactam-associated neutropenia
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Β-lactam-associated neutropenia /
Revision as of 03:11, 24 July 2022 by Aidan (talk | contribs) (Created page with "{{DISPLAYTITLE:β-lactam-associated neutropenia}} == Background == * Adverse reaction to β-lactam antibiotics occurring in about 1 to 10% of prolonged courses * Higher risk with penicillin G, nafcillin, oxacillin, piperacillin-tazobactam, ceftriaxone, and ceftaroline * Risk increases with cumulative exposure * Mechanism is unclear; may be some combination of a direct toxic effect or an Hypersensitivity reaction|immune-mediated...")
Background
- Adverse reaction to β-lactam antibiotics occurring in about 1 to 10% of prolonged courses
- Higher risk with penicillin G, nafcillin, oxacillin, piperacillin-tazobactam, ceftriaxone, and ceftaroline
- Risk increases with cumulative exposure
- Mechanism is unclear; may be some combination of a direct toxic effect or an immune-mediated hypersensitivity reaction
Clinical Manifestations
- Neutropenia
- Can progress to agranulocytosis
Management
- Stop the offending agent
- Other β-lactam antibiotics are probably still safe to use
Further Reading
- A Review of β-Lactam-Associated Neutropenia and Implications for Cross-reactivity. Ann Pharmacother. 2021;55(8):1037-1049. doi: 10.1177/1060028020975646
