Tuberculoma

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Background

Clinical Manifestations

  • Often asymptomatic
  • In CNS, may present with headache, seizures, or focal neurological deficits

Differential Diagnosis

Diagnosis

  • Based on imaging, with ring-enhancing lesion with surrounding edema
  • If there is uncertainty about the diagnosis, may need biopsy

Management

  • Manage per primary diagnosis, with at least 6 months of standard therapy
  • Dexamethasone can be considered for CNS tuberculoma with surrounding vasogenic edema and neurologic symptoms

References

  1. ^  Deborah J Nicolls, Mark King, David Holland, Jennifer Bala, Carlos del Rio. Intracranial tuberculomas developing while on therapy for pulmonary tuberculosis. The Lancet Infectious Diseases. 2005;5(12):795-801. doi:10.1016/s1473-3099(05)70299-1.