Osteomyelitis with orthopedic hardware

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Management

  • Following complete explantation, 4 to 6 weeks of IV antibiotics
  • With retained hardware, 6 weeks of IV followed by stepdown to oral therapy for another 3 to 6 months (or lifelong suppression)

Further Reading

  • Four versus six weeks of antibiotic therapy for osteoarticular infections after implant removal: a randomized trial. J Antimicrob Chemother. 2019(74)8:2394-2399. doi: 10.1093/jac/dkz202