Antibiotic-associated diarrhea
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Differential Diagnosis
- Clostridioides difficile
- Other microbes: Clostridium perfringens type A (food poisoning), Staphylococcus aureus, Salmonella enterica, and possible Candida albicans
- Direct effects on intestinal tract
- Erythromycin and clavulanate cause increased motility
- Penicillins may rarely cause a segmental colitis
- Effects on the fecal microbiota
- Decreased carbohydrate metabolism, leading to osmotic diarrhea
- Breakdown of primary bile acids, leading to secretory diarrhea
- Concomitant use of laxatives, antacids, contrast, lactose- or sorbitol-containing products, NSAIDs, antiarrhythmic drugs, and cholinergic drugs
References
- ^ Sara Blaabjerg, Daniel Artzi, Rune Aabenhus. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics. 2017;6(4):21. doi:10.3390/antibiotics6040021.