Eagle phenomenon

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  • Refers to the paradoxical decreased activity at antibiotic concentrations above some optimal level
  • Thought to be related to reduced expression of PBPs in stationary phase growth

References

  1. ^  Anggia Prasetyoputri, Angie M. Jarrad, Matthew A. Cooper, Mark A.T. Blaskovich. The Eagle Effect and Antibiotic-Induced Persistence: Two Sides of the Same Coin?. Trends in Microbiology. 2019;27(4):339-354. doi:10.1016/j.tim.2018.10.007.
  2. ^  Harry Eagle, A. D. Musselman. The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms. The Journal of Experimental Medicine. 1948;88(1):99-131. doi:10.1084/jem.88.1.99.

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