Eagle phenomenon
From IDWiki
- Refers to the paradoxical decreased antimicrobial activity at antibiotic concentrations above some optimal level1
- That is, there is more bacteria surviving when exposed to concentrations far higher than MBC compared to those exposed to concentrations at or just above the MBC
- Although first described with penicillin and Gram-positive cocci2, the phenomenon has since been observed across many bacteria and many antibiotics
References
- ^ Anggia Prasetyoputri, Angie M. Jarrad, Matthew A. Cooper, Mark A.T. Blaskovich. The Eagle Effect and Antibiotic-Induced Persistence: Two Sides of the Same Coin?. Trends in Microbiology. 2019;27(4):339-354. doi:10.1016/j.tim.2018.10.007.
- ^ Harry Eagle, A. D. Musselman. The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms. The Journal of Experimental Medicine. 1948;88(1):99-131. doi:10.1084/jem.88.1.99.
