Bedaquiline

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  • Antituberculosis antibiotic used as second-line therapy
  • Inhibits the ATP synthase proton pump in mycobacteria
  • Member of the diarylquinoline class of antibiotics
  • Adverse events include QT prolongation, hepatitis, and possibly an increased risk of death
    • Others: arthralgias, dizziness, headache, hyperuriemia, insomnia, myalgia, nausea, prolonged ECG QT interval, pruritus, and vomiting